David Gilham

Affiliations

Clinical and Experimental Immunotherapy Group Institute of Cancer Sciences, Manchester Academic Healthcare Science Centre Manchester UK.

Publications (16)

Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease.

Current opinion in nephrology and hypertension

Avec: Mathias Haarhaus , Dean Gilham , Ewelina Kulikowski , Per Magnusson , Kamyar Kalantar-Zadeh

Apabetalone downregulates factors and pathways associated with vascular calcification.

Atherosclerosis

Avec: Dean Gilham , Laura M Tsujikawa , Christopher D Sarsons , Christopher Halliday , Sylwia Wasiak , Stephanie C Stotz , Ravi Jahagirdar , Michael Sweeney , Jan O Johansson , Norman C W Wong , Kamyar Kalantar-Zadeh , Ewelina Kulikowski

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.

Biomedicines

Avec: Dean Gilham , Audrey L Smith , Li Fu , Dalia Y Moore , Abenaya Muralidharan , St Patrick M Reid , Stephanie C Stotz , Jan O Johansson , Michael Sweeney , Norman C W Wong , Ewelina Kulikowski , Dalia El-Gamal

Evidence of clinical efficacy of a first generation CD19 CAR T cell in B cell malignancies.

EJHaem

Avec: Kyrillus S Shohdy , Manon Pillai , Ryan Guest , Dominic Rothwell , Natalia Kirillova , Shien Chow , David Gilham , Fiona Thistlethwaite , Robert Hawkins

Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation.

International immunopharmacology

Avec: Li Fu , Dean Gilham , Stephanie C Stotz , Christopher D Sarsons , Brooke D Rakai , Laura M Tsujikawa , Sylwia Wasiak , Jan O Johansson , Michael Sweeney , Norman C W Wong , Ewelina Kulikowski

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.

Clinical epigenetics

Avec: Laura M Tsujikawa , Li Fu , Shovon Das , Christopher Halliday , Brooke D Rakai , Stephanie C Stotz , Christopher D Sarsons , Dean Gilham , Emily Daze , Sylwia Wasiak , Deborah Studer , Kristina D Rinker , Michael Sweeney , Jan O Johansson , Norman C W Wong , Ewelina Kulikowski

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.

Biomedicines

Avec: Dean Gilham , Sylwia Wasiak , Brooke D Rakai , Li Fu , Laura M Tsujikawa , Christopher D Sarsons , Agostina Carestia , Kenneth Lebioda , Jan O Johansson , Michael Sweeney , Kamyar Kalantar-Zadeh , Ewelina Kulikowski

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response

Cardiovascular therapeutics

Avec: Sylwia Wasiak , Dean Gilham , Emily Daze , Laura M Tsujikawa , Christopher Halliday , Stephanie C Stotz , Brooke D Rakai , Li Fu , Ravi Jahagirdar , Michael Sweeney , Jan O Johansson , Norman C W Wong , Ewelina Kulikowski

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Cell

Avec: Richard J Mills , Sean J Humphrey , Patrick R J Fortuna , Mary Lor , Simon R Foster , Gregory A Quaife-Ryan , Rebecca L Johnston , Troy Dumenil , Cameron Bishop , Rajeev Rudraraju , Daniel J Rawle , Thuy Le , Wei Zhao , Leo Lee , Charley Mackenzie-Kludas , Neda R Mehdiabadi , Christopher Halliday , Dean Gilham , Li Fu , Stephen J Nicholls , Jan Johansson , Michael Sweeney , Norman C W Wong , Ewelina Kulikowski , Kamil A Sokolowski , Brian W C Tse , Lynn Devilée , Holly K Voges , Liam T Reynolds , Sophie Krumeich , Ellen Mathieson , Dad Abu-Bonsrah , Kathy Karavendzas , Brendan Griffen , Drew Titmarsh , David A Elliott , James McMahon , Andreas Suhrbier , Kanta Subbarao , Enzo R Porrello , Mark J Smyth , Christian R Engwerda , Kelli P A MacDonald , Tobias Bald , David E James , James E Hudson

Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Laura M Tsujikawa , Olesya A Kharenko , Stephanie C Stotz , Brooke D Rakai , Christopher D Sarsons , Dean Gilham , Sylwia Wasiak , Li Fu , Michael Sweeney , Jan O Johansson , Norman C W Wong , Ewelina Kulikowski

Implementing services for pediatric cystic fibrosis treatment in a community hospital.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Avec: Paige Grube , Heather Rodman , Sarah Ferrell , Denise Gilham , Allyson Gaylor , Karen Dunkelberger

The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation

Translational neuroscience

Avec: Sylwia Wasiak , Li Fu , Emily Daze , Dean Gilham , Brooke D Rakai , Stephanie C Stotz , Laura M Tsujikawa , Chris D Sarsons , Deborah Studer , Kristina D Rinker , Ravi Jahagirdar , Norman C W Wong , Michael Sweeney , Jan O Johansson , Ewelina Kulikowski

CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth.

JCI insight

Avec: Xiaodong Zhuang , Federica Maione , Joseph Robinson , Michael Bentley , Baksho Kaul , Katharine Whitworth , Neeraj Jumbu , Elizabeth Jinks , Jonas Bystrom , Pietro Gabriele , Elisabetta Garibaldi , Elena Delmastro , Zsuzsanna Nagy , David Gilham , Enrico Giraudo , Roy Bicknell , Steven P Lee

Autoantibodies to mRNA processing pathways (glycine and tryptophan-rich bodies antibodies): prevalence and clinical utility in a South Australian cohort.

Pathology

Avec: Mahmood Al Kindi , John Cassidy , Dianne Gilham , Marvin Fritzler , Pravin Hissaria

Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.

Atherosclerosis

Avec: Sylwia Wasiak , Laura M Tsujikawa , Emily Daze , Dean Gilham , Stephanie C Stotz , Brooke D Rakai , Chris D Sarsons , Li Fu , Salman Azhar , Ravi Jahagirdar , Michael Sweeney , Jan O Johansson , Norman C W Wong , Ewelina Kulikowski

Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells.

Biomedicines

Avec: Christopher D Sarsons , Dean Gilham , Laura M Tsujikawa , Sylwia Wasiak , Li Fu , Brooke D Rakai , Stephanie C Stotz , Agostina Carestia , Michael Sweeney , Ewelina Kulikowski

Réseau de co-auteurs

Dean Gilham 12 collaborations

Ewelina Kulikowski 12 collaborations

Michael Sweeney 11 collaborations

Li Fu 10 collaborations

Laura M Tsujikawa 9 collaborations

Sylwia Wasiak 9 collaborations

Stephanie C Stotz 9 collaborations

Jan O Johansson 9 collaborations

Norman C W Wong 9 collaborations

Brooke D Rakai 8 collaborations

Christopher D Sarsons 6 collaborations

Christopher Halliday 4 collaborations

Ravi Jahagirdar 4 collaborations

Emily Daze 4 collaborations

Kamyar Kalantar-Zadeh 3 collaborations

Deborah Studer 2 collaborations

Kristina D Rinker 2 collaborations

Agostina Carestia 2 collaborations

Chris D Sarsons 2 collaborations

Mathias Haarhaus 1 collaboration

Per Magnusson 1 collaboration

Audrey L Smith 1 collaboration

Dalia Y Moore 1 collaboration

Abenaya Muralidharan 1 collaboration

St Patrick M Reid 1 collaboration

Dalia El-Gamal 1 collaboration

Kyrillus S Shohdy 1 collaboration

Manon Pillai 1 collaboration

Ryan Guest 1 collaboration

Dominic Rothwell 1 collaboration

Natalia Kirillova 1 collaboration

Shien Chow 1 collaboration

Fiona Thistlethwaite 1 collaboration

Robert Hawkins 1 collaboration

Shovon Das 1 collaboration

Kenneth Lebioda 1 collaboration

Richard J Mills 1 collaboration

Sean J Humphrey 1 collaboration

Patrick R J Fortuna 1 collaboration

Mary Lor 1 collaboration

Simon R Foster 1 collaboration

Gregory A Quaife-Ryan 1 collaboration

Rebecca L Johnston 1 collaboration

Troy Dumenil 1 collaboration

Cameron Bishop 1 collaboration

Rajeev Rudraraju 1 collaboration

Daniel J Rawle 1 collaboration

Thuy Le 1 collaboration

Wei Zhao 1 collaboration

Leo Lee 1 collaboration

Charley Mackenzie-Kludas 1 collaboration

Neda R Mehdiabadi 1 collaboration

Stephen J Nicholls 1 collaboration

Jan Johansson 1 collaboration

Kamil A Sokolowski 1 collaboration

Brian W C Tse 1 collaboration

Lynn Devilée 1 collaboration

Holly K Voges 1 collaboration

Liam T Reynolds 1 collaboration

Sophie Krumeich 1 collaboration

Ellen Mathieson 1 collaboration

Dad Abu-Bonsrah 1 collaboration

Kathy Karavendzas 1 collaboration

Brendan Griffen 1 collaboration

Drew Titmarsh 1 collaboration

David A Elliott 1 collaboration

James McMahon 1 collaboration

Andreas Suhrbier 1 collaboration

Kanta Subbarao 1 collaboration

Enzo R Porrello 1 collaboration

Mark J Smyth 1 collaboration

Christian R Engwerda 1 collaboration

Kelli P A MacDonald 1 collaboration

Tobias Bald 1 collaboration

David E James 1 collaboration

James E Hudson 1 collaboration

Olesya A Kharenko 1 collaboration

Paige Grube 1 collaboration

Heather Rodman 1 collaboration

Sarah Ferrell 1 collaboration

Denise Gilham 1 collaboration

Allyson Gaylor 1 collaboration

Karen Dunkelberger 1 collaboration

Xiaodong Zhuang 1 collaboration

Federica Maione 1 collaboration

Joseph Robinson 1 collaboration

Michael Bentley 1 collaboration

Baksho Kaul 1 collaboration

Katharine Whitworth 1 collaboration

Neeraj Jumbu 1 collaboration

Elizabeth Jinks 1 collaboration

Jonas Bystrom 1 collaboration

Pietro Gabriele 1 collaboration

Elisabetta Garibaldi 1 collaboration

Elena Delmastro 1 collaboration

Zsuzsanna Nagy 1 collaboration

Enrico Giraudo 1 collaboration

Roy Bicknell 1 collaboration

Steven P Lee 1 collaboration

Mahmood Al Kindi 1 collaboration

John Cassidy 1 collaboration

Dianne Gilham 1 collaboration

Marvin Fritzler 1 collaboration

Pravin Hissaria 1 collaboration

Salman Azhar 1 collaboration